The proactive wet-wrap method with diluted corticosteroids versus emollients in children with聽atopic dermatitis: A prospective, randomized, double-blind, placebo-controlled trial

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• 作者：Sherief R. Janmohamed ; MD^a ; ^d ; Arnold P. Oranje ; MD ; PhD^a ; ^d ; ^e ; ^{a.oranje@inter.nl.net" class="auth_mail} ; Arjan C. Devillers ; MD ; PhD^e ; Dimitris Rizopoulos ; PhD^c ; Marinus C.G. van Praag ; MD ; PhD^f ; Dirk Van Gysel ; MD ; PhD^g ; Marleen Goeteyn ; MD^h ; Flora B. de Waard-van der Spek ; MD ; PhD^b ; ^d
• 关键词：atopic dermatitis ; diluted corticosteroids ; emollients ; eczema ; long-term-intervention ; wet-wrap treatment
• 刊名：Journal of the American Academy of Dermatology
• 出版年：June 2014
• 年：2014
• 卷：70
• 期：6
• 页码：1076-1082
• 全文大小：331 K

文摘

Wet-wrap treatment (WWT) has been advocated as a relatively effective treatment in children with severe atopic dermatitis (AD). WWT often serves as crisis intervention for AD.

Objectives

We sought to evaluate the use of WWT with diluted corticosteroids in comparison with emollient in children with severe AD during 4 weeks in a proactive schedule during which the frequency of corticosteroid applications was tapered.

Methods

A randomized, double-blind, placebo-controlled study was performed in children aged 6 months to 10 years with severe AD (objective SCORAD at least 40 ± 5), comparing WWT with diluted corticosteroids (1:3 mometasone furoate 0.1% ointment and for the face 1:19 mometasone furoate 0.1% ointment under a mask) with emollient (petrolatum 20% in cetomacrogol cream). The primary outcome was improvement of the objective SCORAD; secondary outcomes included Patient-Oriented Eczema Measure and quality-of-life index.

Results

WWT with diluted corticosteroids acted faster and was more efficacious than WWT with emollients. Best results were obtained in age groups 6 to 9 years and 0 to 3 years. The difference in efficacy evaluated by objective SCORAD was significant at all measuring points. This also applied to the quality-of-life index.

Limitations

The study group was relatively small.

Conclusions

WWT for severe AD is an effective therapy option for at least a period of 4 weeks.