Structure and antioxidant superoxide dismutase activity of copper(II) hydrazone complexes

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• 作者：Yogendra Pratap Singh^a ; Ram N. Patel^a ; ^{rnp64@ymail.com} ; Yogendra Singh^a ; Ray J. Butcher^b ; Pradeep Kumar Vishakarma^c ; R.K. Bhubon Singh^d
• 关键词：Mixed ligand complexes ; Antioxidant SOD mimics ; X-ray analysis ; Electron paramagnetic resonance(epr) spectra ; Cyclic voltammetry (CV)
• 刊名：Polyhedron
• 出版年：2017
• 出版时间：28 January 2017
• 年：2017
• 卷：122
• 期：Complete
• 页码：1-15
• 全文大小：2670 K
• 卷排序：122

文摘

Three new mixed ligand hydrazone complexes viz., [Cu(L)(neocuprin)]NO3·H2O 1, [Cu(L)(HL)]ClO42 and [Cu2(2-(2-pyridyl)benzimidazole)2(L)2]ClO43 (L = N′-[(E)-phenyl(pyridin-2-yl)methylidene]furan-2-carbohydrazide) have been synthesized by the biomimetic synthesis strategy and their structures were determined by single crystals X-ray analysis. The effect of differing contagious, as well as the rotational conformational versatility of HL, was demonstrated by the difference in structures of complexes 1–3. These complexes exhibited the antioxidant superoxide dismutase enzymatic activity. The geometry of copper(II) atom in complex 1 is distorted square pyramidal while in complexes 2 and 3 the geometries around copper(II) atoms are distorted octahedral. Magnetic measurements and epr spectroscopy of binuclear complex 3 have shown antiferromagnetic exchange interaction with a coupling constant (J) = −10.87 cm−1. Electronic and spectral properties of these newly synthesized hydrazone complexes (1–3) are interpreted by DFT and TDDFT calculations. The results reveal that molecular structures have significant effect on antioxidant superoxide activity. Such biological experimental values (antioxidant SOD activity data) are indicative of the promising application of these complexes into the bioinorganic chemistry of superoxide dismutase.