A general and efficient stereoselective synthesis of γ-azido-tetrahydrofuran carboxylic acids from glycals

详细信息    查看全文

• 作者：P. Venkat Reddy ; L. Vijaya Raghava Reddy ; Brijesh Kumar ; Rishi Kumar ; Prakas R. Maulik ; Arun K. Shaw
• 关键词：γ ; -Sugar amino acids ; Peptidomimetics ; Glycal ; Perlin hydrolysis
• 刊名：Tetrahedron
• 出版年：2008
• 出版时间：25 February 2008
• 年：2008
• 卷：64
• 期：9
• 页码：2153-2159
• 全文大小：513 K

文摘

An efficient, direct and general synthesis of enantiopure γ-azido-tetrahydrofuran carboxylic acid monomers (5–8) from commercially available glycals, suitable to design peptidomimetic oligomers with predisposed conformation, is described. The single crystal X-ray study of 8 showed that the compound crystallized in orthorhombic space group. The crystal-packing showed the presence of weak intermolecular C–HO and aliphatic C–Hπ interactions.