Isolation of optically active nevirapine, a dipyridodiazepinone metabolite from the seeds of Cleome viscosa

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• 作者：Sunil K. Chattopadhyay ; Arnab Chatterjee ; Sudeep T ; on ; Prakas R. Maulik ; Ruchir Kant
• 刊名：Tetrahedron
• 出版年：2011
• 出版时间：14 January 2011
• 年：2011
• 卷：67
• 期：2
• 页码：452-454
• 全文大小：233 K

文摘

The optically active nevirapine, a natural analogue of the previously designed and synthesized optically inactive nevirapine, a non-nucleoside inhibitor of HIV-1 reverse transcriptase, has been isolated and fully characterized from the seeds of Cleome viscosa. The structure of natural nevirapine has been confirmed by X-ray crystallography. It is an interesting discovery to find out that optically inactive nevirapine was designed and synthesized before the isolation of optically active nevirapine from the seeds of C.viscosa.