Cytotoxic cycloartane triterpene and rare isomeric bisclerodane diterpenes from the leaves of Polyalthia longifolia var. pendula

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• 作者：Koneni V. Sashidhara ; Suriya P. Singh ; Ruchir Kant ; Prakas R. Maulik ; Jayanta Sarkar ; Sanjeev Kanojiya ; K. Ravi Kumar
• 关键词：Polyalthia longifolia var. pendula ; Cycloartane ; Bisclerodane imide ; Cervical carcinoma ; Tandem mass spectroscopy
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2010
• 出版时间：1 October 2010
• 年：2010
• 卷：20
• 期：19
• 页码：5767-5771
• 全文大小：514 K

文摘

A 24-methylenecycloartane-3β, 16β, 23β-triol, Longitriol (1), rare bisclerodane imides, Longimide A (2) and previously known Longimide B (3) were isolated from ethanolic extract of the leaves of Polyalthia longifolia var. pendula. This is the first example of isolation of any cycloartane triterpene from this plant source. Structures were determined by extensive (1D and 2D NMR) spectroscopic data analysis combined with ESI MS/MS fragmentation and X-ray analysis. Furthermore, Compounds 1 and 2 were evaluated for their cytotoxic effects against four human cancer cell lines and found to be most active against cervical carcinoma cell lines with IC₅₀ value of 10.03 and 4.12 μg/mL, respectively.