Adipose tissue-resident immune cells: key players in immunometabolism

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• 作者：Henk S. Schipper ; Berent Prakken ; Eric Kalkhoven ; Marianne Boes
• 关键词：obesity ; adipose tissue ; inflammation ; immunometabolism ; energy-on-demand model
• 刊名：Trends in Endocrinology and Metabolism
• 出版年：2012
• 出版时间：August, 2012
• 年：2012
• 卷：23
• 期：8
• 页码：407-415
• 全文大小：1274 K

文摘

Adipose tissue (AT) plays a pivotal role in whole-body lipid and glucose homeostasis. AT exerts metabolic control through various immunological mechanisms that instigated a new research field termed immunometabolism. Here, we review AT-resident immune cells and their role as key players in immunometabolism. In lean subjects, AT-resident immune cells have housekeeping functions ranging from apoptotic cell clearance to extracellular matrix remodeling and angiogenesis. However, obesity provides bacterial and metabolic danger signals that mimic bacterial infection, and drives a shift in immune-cell phenotypes and numbers, classified as a prototypic T helper 1 (Th1) inflammatory response. The resulting AT inflammation and insulin resistance link obesity to its metabolic sequel, and suggests that targeted immunomodulatory interventions may be beneficial for obese patients.