Wild-type hen egg white lysozyme aggregation in vitro can form self-seeding amyloid conformational variants
详细信息 查看全文
- 作者：Vishwanath Sivalingam ; Nalla Lakshmi Prasanna ; Neetu Sharma1 ; Archana Prasad1 ; Basant K Patel ; basantkpatel@iith.ac.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Amyloid ; Hen egg white lysozyme ; Amyloid variants ; AFM ; Dynamic light scattering
- 刊名：Biophysical Chemistry
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：219
- 期：Complete
- 页码：28-37
- 全文大小：1657 K
文摘
- •
Full-length HEWL forms amyloid-like aggregates at pH 2.0, 37 °C under quiescent and agitated conditions.
- •
Agitated and static HEWL aggregates display differences in AFM morphologies and stability.
- •
Amyloid seeds from agitated and static HEWL amyloid aggregates show conformational incompatibility in seeding.