Bisphosphonates: Pharmacokinetics, bioavailability, mechanisms of action, clinical applications in children, and effects on tooth development

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• 作者：Ana Prates Soares^a ; ^{anapratess@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Renan Fernandes do Espí ; rito Santo^b ; ^{r.fernandes88@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Sé ; rgio Roberto Peres Line^c ; ^{serglin@unicamp.br" class="auth_mail" title="E-mail the corresponding author} ; Maria das Graç ; as Farias Pinto^d ; ^{pintogra@ufba.br" class="auth_mail" title="E-mail the corresponding author} ; Pablo de Moura Santos^e ; ^{pablomoura@ufba.br" class="auth_mail" title="E-mail the corresponding author} ; Maria Betâ ; nia Pereira Toralles^f ; ^{m.toralles@uol.com.br" class="auth_mail" title="E-mail the corresponding author} ; Alexandre Ribeiro do Espí ; rito Santo^f ; ^{arespiritosanto@ufba.br" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Bisphosphonates ; Tooth ; Odontogenesis ; Dentin ; Dental enamel
• 刊名：Environmental Toxicology and Pharmacology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：42
• 期：Complete
• 页码：212-217
• 全文大小：698 K

文摘

Bisphosphonates (BPs) avidly bind to calcium crystals and inhibit osteoclastic bone resorption, making them useful for treatment of skeletal disorders such as osteoporosis, Paget's disease, osteogenesis imperfecta and metastatic bone diseases. BPs therapeutically act by causing toxic effects on osteoclasts or interfering with specific intracellular pathways in those cells. BPs that possess nitrogen in their composition are called nitrogen-containing BPs (NBPs) and include alendronate, pamidronate, risedronate, ibandronate, and zoledronate. Simple BPs or non-NBPs do not have nitrogen in their composition, include etiodronate and clodronate, and were the first to be tested in animals and clinically used. Because BPs may be administered to pregnant women or children during deciduous and permanent teeth development, it is expected that they might disturb tooth eruption and development. A review of current literature on pharmacokinetics, bioavailability, mechanisms of action, and clinical applications of BPs in children, and their effects on tooth eruption and development is presented.