The Multifaceted Roles of PRDM16: Adipose Biology and Beyond

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• 作者：Jingyi Chi¹ ; Paul Cohen¹ ; ^{pcohen@rockefeller.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：PRDM16 ; adipose ; brown fat ; beige fat ; PRDM ; transcriptional regulation
• 刊名：Trends in Endocrinology & Metabolism
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：27
• 期：1
• 页码：11-23
• 全文大小：2474 K

文摘

The PRDM [PRDI-BFI (positive regulatory domain I-binding factor 1) and RIZ1 (retinoblastoma protein-interacting zinc finger gene 1) homologous domain containing] protein family is involved in a spectrum of biological processes including cell fate determination and development. These proteins regulate transcription through intrinsic chromatin-modifying activity or by complexing with histone-modifying or other nuclear proteins. Studies have indicated crucial roles for PRDM16 in the determination and function of brown and beige fat as well as in hematopoiesis and cardiac development, highlighting the importance of PRDM16 in developmental processes in different tissues. More recently, PRDM16 mutations were also identified in humans. The substantial progress in understanding the mechanism underlying the action of PRDM16 in adipose biology may have relevance to other PRDM family members, and this new knowledge has the potential to be exploited for therapeutic benefit.