Longitudinal T1 relaxation rate (R1) captures changes in short-term Mn exposure in welders

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• 作者：Mechelle M. Lewis^a ; ^b ; Michael R. Flynn^c ; Eun-Young Lee^a ; Scott Van Buren^d ; Eric Van Buren^d ; Guangwei Du^a ; Rebecca C. Fry^c ; Amy H. Herring^d ; Lan Kong^e ; Richard B. Mailman^a ; ^b ; Xuemei Huang^a ; ^b ; ^f ; ^g ; ^{Xuemei@psu.edu} (Dr.)
• 关键词：GP ; globus pallidus ; HrsW ; hours spent welding ; brazing ; or soldering in the 90&thinsp ; day period preceding MRI ; MRI ; magnetic resonance imaging ; R1 ; T1 relaxation rate ; ROIs ; regions-of-interest ; T1 ; MRI longitudinal relaxation time ; T1WI ; T1-weighted intensity ; TE ; echo time ; TR ; repetition time ; UPDRS ; Unified Parkinson&rsquo ; s Disease Rating Scale ; YrsW ; cumulative lifetime years welding
• 刊名：NeuroToxicology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：57
• 期：Complete
• 页码：39-44
• 全文大小：344 K
• 卷排序：57

文摘

A one-year follow-up study investigated associations between changes in estimated welding exposure and changes in purported Mn biomarkers in welders with chronic, low-level exposure. Traditional measures (blood Mn levels or the pallidal index) did not correlate with changes in estimated welding exposure levels (hours welding in the 90-day period prior to study visit). Changes in R1 values correlated significantly with changes in estimated welding exposure levels (hours welding in the prior 90-day period) in areas both within and outside basal ganglia regions. R1 may serve as a marker to capture short-term dynamics of Mn brain accumulation and clearance.