Brucella pinnipedialis hooded seal (Cystophora cristata) strain in the mouse model with concurrent exposure to PCB 153

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• 作者：Ingebjø ; rg H. Nymo^a ; ^h ; ¹ ; ^{ingebjorg.h.nymo@uit.no" class="auth_mail} ; ^{ingebjorg.nymo@gmail.com" class="auth_mail} ; Carlos G. das Neves^b ; Morten Tryland^a ; ^h ; ¹ ; Bå ; rd-Jø ; rgen Bå ; rdsen^c ; ^h ; Renato Lima Santos^d ; Andreia Pereira Turchetti^d ; Andrew M. Janczak^e ; Berit Djø ; nne^b ; Elisabeth Lie^f ; ^g ; Vidar Berg^g ; Jacques Godfroid^a ; ^h ; ¹
• 关键词：BALB/c ; Brucella spp. ; Cell mediated immunity ; In vivo ; Immunoglobulins ; Immunology ; Pathogenicity ; Persistent organic pollutants
• 刊名：Comparative Immunology, Microbiology and Infectious Diseases
• 出版年：May 2014
• 年：2014
• 卷：37
• 期：3
• 页码：195-204
• 全文大小：852 K

文摘

Brucellosis, a worldwide zoonosis, is linked to reproductive problems in primary hosts. A high proportion of Brucella-positive hooded seals (Cystophora cristata) have been detected in the declined Northeast Atlantic stock. High concentrations of polychlorinated biphenyls (PCBs) have also been discovered in top predators in the Arctic, including the hooded seal, PCB 153 being most abundant. The aim of this study was to assess the pathogenicity of Brucella pinnipedialis hooded seal strain in the mouse model and to evaluate the outcome of Brucella spp. infection after exposure of mice to PCB 153. BALB/c mice were infected with B. pinnipedialis hooded seal strain or Brucella suis 1330, and half from each group was exposed to PCB 153 through the diet. B. pinnipedialis showed a reduced pathogenicity in the mouse model as compared to B. suis 1330. Exposure to PCB 153 affected neither the immunological parameters, nor the outcome of the infection. Altogether this indicates that it is unlikely that B. pinnipedialis contribute to the decline of hooded seals in the Northeast Atlantic.