Cellular prion protein modulates defensive attention and innate fear-induced behaviour evoked in transgenic mice submitted to an agonistic encounter with the tropical coral snake Oxyrhopus guibei

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• 作者：Bruno Lobã ; o-Soares ; Roger Walz ; Rui Daniel Schrö ; der Prediger ; Renato Leonardo Freitas ; Fabrí ; cio Calvo ; Marino Muxfeldt Bianchin ; Joã ; o Pereira Leite ; Michele Christine L ; emberger ; N
• 关键词：Cellular prion protein (PrP^C) ; Olfactory discrimination task ; Anxiety ; Innate fear-related responses ; Genetically modified mice ; Non-venomous coral snake ; Prey versus predator paradigm
• 刊名：Behavioural Brain Research
• 出版年：2008
• 出版时间：12 December 2008
• 年：2008
• 卷：194
• 期：2
• 页码：129-137
• 全文大小：613 K

文摘

The cellular prion protein (PrP^C) is a neuronal anchored glycoprotein that has been associated with distinct functions in the CNS, such as cellular adhesion and differentiation, synaptic plasticity and cognition. Here we investigated the putative involvement of the PrP^C in the innate fear-induced behavioural reactions in wild-type (WT), PrP^C knockout (Prnp^0/0) and the PrP^C overexpressing Tg-20 mice evoked in a prey versus predator paradigm. The behavioural performance of these mouse strains in olfactory discrimination tasks was also investigated. When confronted with coral snakes, mice from both Prnp^0/0 and Tg-20 strains presented a significant decrease in frequency and duration of defensive attention and risk assessment, compared to WT mice. Tg-20 mice presented decreased frequency of escape responses, increased exploratory behaviour, and enhancement of interaction with the snake, suggesting a robust fearlessness caused by PrP^C overexpression. Interestingly, there was also a discrete decrease in the attentional defensive response (decreased frequency of defensive alertness) in Prnp^0/0 mice in the presence of coral snakes. Moreover, Tg-20 mice presented an increased exploration of novel environment and odors. The present findings indicate that the PrP^C overexpression causes hyperactivity, fearlessness, and increased preference for visual, tactile and olfactory stimuli-associated novelty, and that the PrP^c deficiency might lead to attention deficits. These results suggest that PrP^c exerts an important role in the modulation of innate fear and novelty-induced exploration.