The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice
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- 作者：Blagaic ; Alenka Boban ; Blagaic ; Vladimir ; Romic ; Zeljko ; Sikiric ; Predrag
- 关键词：Stable gastric pentadecapeptide BPC 157 ; Acute alcohol intoxication ; Withdrawal/chronic alcohol consumption
- 刊名：European Journal of Pharmacology
- 出版年：2004
- 出版时间：September 24, 2004
- 年：2004
- 卷：499
- 期：3
- 页码：285-290
- 全文大小：97.4 K
文摘
The stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W.1419), which was promising in inflammatory bowel disease (PL-10, PLD-116, PL-14736, Pliva) trials, protects against both acute and chronic alcohol-induced lesions in stomach and liver, but also, given peripherally, affects various centrally mediated disturbances. Now, in male NMRI mice BPC 157 (10 pg intraperitoneally, 10 ng and 10 ??g, intraperitoneally or intragastrically) (i) strongly opposed acute alcohol (4 g/kg intraperitoneally) intoxication (i.e., quickly produced and sustained anesthesia, hypothermia, increased ethanol blood values, 25 % fatality, 90-min assessment period) given before or after ethanol, and (ii) when given after abrupt cessation of ethanol (at 0 or 3 or 7 h withdrawal time), attenuated withdrawal (assessed through 24 hours) after 20 % -alcohol drinking (7.6 g/kg) through 13 days, with provocation on the 14th day.