Phenolic glycosides from Dodecadenia grandiflora and their glucose-6-phosphatase inhibitory activity

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• 作者：Manmeet Kumar ; Preeti Rawat ; Mohammad Faheem Khan ; Akhilesh K. Tamarkar ; Arvind K. Srivastava ; Kamal R. Arya ; Rakesh Maurya
• 关键词：Dodecadenia grandiflora ; Glucose-6-phosphatase ; Phenolic glycoside ; Coumaroyl
• 刊名：Fitoterapia
• 出版年：2010
• 出版时间：September 2010
• 年：2010
• 卷：81
• 期：6
• 页码：475-479
• 全文大小：308 K

文摘

Phytochemical investigation of Dodecadenia grandiflora leaves led to the isolation and identification of three phenolic glycosides, designated 1-[(4′-O-(E)-p-coumaroyl)-β-d-glucopyranosyl]-oxy-2-phenol (1), 1-[(6′-O-(E)-p-coumaroyl)-β-d-glucopyranosyl]-oxy-2-phenol (2) and 1-[O-β-d-glucopyranosyl(1→2)-β-d-glucopyranosyl]-oxy-2-phenol (3), along with nine known compounds. Compounds 1, 2, 5 and 9 exhibited significant glucose-6-phosphatase inhibitory activity (63.7, 66.9, 82.9 and 85.4 % ) with IC₅₀ values of 88.5, 81.0, 51 and 50 μM respectively. On the basis of biological results, a structure–activity relationship has been discussed.