Anti-osteoporotic constituents from Indian medicinal plants
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- 作者：Manmeet Kumar ; Preeti Rawat ; Preeti Dixit ; Devendra Mishra ; Abnish K. Gautam ; Rashmi P ; ey ; Divya Singh ; Naibedya Chattopadhyay ; Rakesh Maurya
- 关键词：Allophylus serratus ; Cissus quadrangularis ; Vitex negundo ; Osteogenic ; Osteoblast ; Differentiation
- 刊名：Phytomedicine
- 出版年：2010
- 出版时间：November 2010
- 年：2010
- 卷：17
- 期：13
- 页码：993-999
- 全文大小：776 K
文摘
The objective of this study was to determine the in vitro osteogenic activities of selected medicinal plants used traditionally in India. The compounds isolated from three plants viz. Allophylus serratus, Cissus quadrangularis and Vitex negundo were evaluated for their in vitro osteogenic activities. Primary cultures of osteoblasts were used to determine the effects of these components on osteoblast functions. Five (4, 6, 9, 12 and 14) of the fourteen compounds isolated led to increase in osteoblast differentiation and mineralization. These findings lend support to the use of Allophylus serratus, Cissus quadrangularis and Vitex negundo in traditional medicine.