Effects of chemokine receptor signalling on cognition-like, emotion-like and sociability behaviours of CCR6 and CCR7 knockout mice
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- 作者：E.J. Jaehne ; B.T. Baune
- 关键词：EAE ; autoimmune encephalomyelitis ; 3× ; Tg AD ; triple transgenic Alzheimer's disease ; LPS ; lipopolysaccharide ; KO ; knockout ; NORT ; novel object recognition test ; EZM ; Elevated Zero Maze ; FST ; forced swim test ; PFC ; prefrontal cortex
- 刊名：Behavioural Brain Research
- 出版年：15 March, 2014
- 年：2014
- 卷：261
- 期：Complete
- 页码：31-39
- 全文大小：919 K
文摘
Inflammation is regarded as an important mechanism of neuropsychiatric disorders. Chemokines, which are a part of the immune system, have effects on various aspects of brain function, but little is known about their effects on behaviour. We have compared the cognition-like behaviour (learning and spatial memory) of CCR6鈭?鈭?/sup> and CCR7鈭?鈭?/sup> mice with wild type (WT) C57BL/6 mice, in the Barnes maze, as well as a range of other behaviours, including exploratory, anxiety and depression-like behaviour, using a battery of tests. Levels of cytokines TNF-伪, IL-1尾 and IL-6 were also measured. In the Barnes maze, CCR7鈭?鈭?/sup> mice were shown to take longer to learn the location of the escape box on the 1st of 4 days of training. In the behavioural battery, CCR6鈭?鈭?/sup> mice showed higher locomotor activity and lower anxiety in the open field test, and a lack of preference for social novelty in a sociability test. CCR7鈭?鈭?/sup> mice behaved much like WT mice, although showed higher anxiety in Elevated Zero Maze. While baseline saccharin preference in a 2-bottle choice test, a test for anhedonia depression-like behaviour, was equal in all strains at baseline, weekly tests showed that both CCR6鈭?鈭?/sup> and CCR7鈭?鈭?/sup> mice developed a decreased preference for saccharin compared to WT over time. There were no differences between strains in any of the cytokines measured. These results suggest that chemokine receptors may play a role in cognition and learning behaviour, as well as anxiety and other behaviours, although the biological mechanisms are still unclear.