Effects of new fluorinated analogues of GABA, pregabalin bioisosters, on the ambient level and exocytotic release of [3H]GABA from rat brain nerve terminals
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- 关键词：GABA ; γ-aminobutyric acid ; FCCP ; carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone ; HEPES ; N-2-hydroxyethylpiperazine-n-2-ethanesulfonic acid ; FGABAs ; fluorinated analogues of γ-aminobutyric acid
- 刊名：Bioorganic & Medicinal Chemistry
- 出版年：2017
- 出版时间：15 January 2017
- 年：2017
- 卷：25
- 期：2
- 页码：759-764
- 全文大小：518 K
- 卷排序：25
文摘
Properties of new synthesized fluorinated analogues of GABA were analyzed. The analogues did not influence the ambient level of [3H]GABA in nerve terminals. The analogues decreased exocytotic release of [3H]GABA from nerve terminals. Comparative analysis of the effects of the analogues and pregabalin was performed.