Group 1 mGlu-family proteins promote neuroadaptation to ethanol and withdrawal-associated hippocampal damage
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- 作者：Anna R. Reynoldsc ; anna.reynolds@uky.edu" class="auth_mail" title="E-mail the corresponding author ; Luke A. Williamsa ; b ; Meredith A. Saundersa ; b ; Mark A. Prendergasta ; b
- 关键词：CIE ; Chronic intermittent ethanol ; mGlu ; Metabotropic glutamate receptor ; NeuN ; Neuron specific nuclear protein
- 刊名：Drug and Alcohol Dependence
- 出版年：2015
- 出版时间：1 November 2015
- 年：2015
- 卷：156
- 期：Complete
- 页码：213-220
- 全文大小：859 K
文摘
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The present studies examine the role of mGluR signaling in ethanol dependence.
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Hippocampal explants are effective as a high-throughout screen of toxicity.
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Group 1 metabotrophic receptor antagonism attenuates hippocampal cytotoxicity.
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Blocking these receptors prior to withdrawal reduces development of dependence.