Social stress alters the severity and onset of the chronic phase of Theiler's virus infection

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• 作者：Robin R. Johnson ; Thomas W. Prentice ; Patrick Bridegam ; Colin R. Young ; Andrew J. Steelman ; Thomas H. Welsh ; C. Jane R. Welsh and Mary W. Meagher
• 关键词：Multiple sclerosis ; Neurodegeneration ; IL-6 ; Social stress ; TMEV
• 刊名：Journal of Neuroimmunology
• 出版年：2006
• 出版时间：June 2006
• 年：2006
• 卷：175
• 期：1-2
• 页码：39-51
• 全文大小：408 K

文摘

Social stress alters the acute phase of Theiler's virus infection (TMEV), a model of multiple sclerosis. Stress applied prior to infection had deleterious disease outcomes, while stress applied concurrent with infection was protective. The current study examined multiple behavioral (motor impairment, open field activity) and immunological measures (IL-6, antibodies to virus and myelin proteins) in both the acute and chronic phases of TMEV. It was found that stress applied prior to infection exacerbated disease outcomes, while concurrent application was protective in both disease phases.