Steroid sulfatase in the human MG-63 preosteoblastic cell line: Antagonistic regulation by glucocorticoids and NFκB
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- 作者：Natasha J. Dias ; Kyle W. Selcer ; selcer@duq.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Steroid sulfatase ; Regulation ; Osteoblast ; Glucocorticoid ; Dexamethasone ; Differentiation ; NFκB ; Inflammation ; Bone
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：420
- 期：Complete
- 页码：85-96
- 全文大小：1217 K
文摘
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STS activity and expression was decreased in differentiating MG-63 cells.
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Dexamethasone and other glucocorticoids decreased STS activity and expression.
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LPS and PMA increased STS activity and expression, BAY-11-7082 decreased it.
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These data indicate that an NFkB pathway upregulates STS expression.
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STS appears to be regulated as an inflammatory response protein.