Fermented papaya preparation modulates the progression of N-methyl-N-nitrosourea induced hepatocellular carcinoma in Balb/c mice

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• 作者：Jhoti Somanah^a ; Srishti Ramsaha^b ; Shalini Verma^c ; Ashok Kumar^d ; Poornima Sharma^e ; Ranjan Kumar Singh^e ; Okezie I. Aruoma^f ; Emmanuel Bourdon^g ; Theeshan Bahorun^a ; ^{tbahorun@uom.ac.mu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Fermented papaya preparation ; N-methyl-N-nitrosourea ; Hepatocellular carcinoma ; Oxidative stress ; Antioxidant enzymes ; Raman laser spectroscopy ; Balb/c mice
• 刊名：Life Sciences
• 出版年：2016
• 出版时间：15 April 2016
• 年：2016
• 卷：151
• 期：Complete
• 页码：330-338
• 全文大小：1520 K

文摘

The medicinal properties of fermented papaya preparation (FPP) derived from Carica papaya fruit was investigated in order to determine its ability to modulate the progression of N-methyl-N-nitrosourea induced hepatocellular carcinoma in Balb/c mice.

Key findings

As well as reducing the physical symptoms associated with N-methyl-N-nitrosourea (MNU)-induced hepatocellular carcinoma, supplementation of Balb/c mice with 500 mg FPP/kg BW for 92 days normalized the blood cell count, led to an increased activity of several key antioxidant enzymes (SOD: + 20%, CAT: + 81%, GPx: + 66.1%, GR: + 54.4%; P < 0.001 vs. MNU control), increased the ferrous reducing antioxidant potential (+ 36.7%, P < 0.001 vs. MNU control) and reduced the extent of lipid peroxidation in the liver by 44.3% (P < 0.001 vs. MNU control).

Significance

Results demonstrated the ability of FPP to preserve the integrity of liver against oxidative damage and protect hepatocytes against irreversible DNA structural modifications induced by MNU, highlighting its potential role as an immune-defense modulator during hepatocarcinoma.