Microbial cell preparation in enteral feeding in critically ill patients: A randomized, double-blind, placebo-controlled clinical trial

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• 作者：Ausama A. Malik^a ; Retnagowri Rajandram^a ; Pei Chien Tah^b ; Vineya-Rai Hakumat-Rai^c ; Kin-Fah Chin^d ; ^{mdskfc@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：AIDS ; acquired immune deficiency syndrome ; APACHE ; Acute Physiology and Chronic Health Evaluation ; BALT ; bronchus-associated lymphoid tissue ; CFU ; colony-forming unit ; CRP ; C-reactive protein ; GALT ; gut-associated lymphoid tissue ; GCP ; Good Clinical Practice ; GRV ; gastric residual volume ; GSN ; gut-specific nutrients ; ICU ; intensive care unit ; IRB ; institutional review board ; MALT ; mucosa-associated lymphoid tissue ; MCP ; microbial cell preparation ; MEC ; Medical Ethics Committee ; MODS ; multiple-or
• 刊名：Journal of Critical Care
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：32
• 期：Complete
• 页码：182-188
• 全文大小：491 K

文摘

Gut failure is a common condition in critically ill patients in the intensive care unit (ICU). Enteral feeding is usually the first line of choice for nutrition support in critically ill patients. However, enteral feeding has its own set of complications such as alterations in gut transit time and composition of gut eco-culture. The primary aim of this study was to investigate the effect of microbial cell preparation on the return of gut function, white blood cell count, C-reactive protein levels, number of days on mechanical ventilation, and length of stay in ICU. A consecutive cohort of 60 patients admitted to the ICU in University Malaya Medical Centre requiring enteral feeding were prospectively randomized to receive either treatment (n = 30) or placebo (n = 30). Patients receiving enteral feeding supplemented with a course of treatment achieved a faster return of gut function and required shorter duration of mechanical ventilation and shorter length of stay in the ICU. However, inflammatory markers did not show any significant change in the pretreatment and posttreatment groups. Overall, it can be concluded that microbial cell preparation enhances gut function and the overall clinical outcome of critically ill patients receiving enteral feeding in the ICU.