Capsaicin inhibits the voltage-operated calcium channels intracellularly in the antral circular myocytes of guinea-pig stomach

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• 作者：Sim ; Jae Hoon ; Kim ; Young Chul ; Kim ; Sung Joon ; Lee ; Sang Jin ; Suh ; Suk Hyo ; Jun ; Jae Yeoul ; et. al.
• 关键词：Capsaicin ; Gastric smooth muscle strip ; Slow waves ; High K⁺ contracture ; Ca²+ channel current
• 刊名：Life Sciences
• 出版年：2001
• 出版时间：April 13, 2001
• 年：2001
• 卷：68
• 期：21
• 页码：2347-2360
• 全文大小：449 K

文摘

Studies of the effect of capsaicin (CAP) on the smooth muscle contractions have shown both contraction and relaxation in various preparations. The direct effect of CAP on gastric smooth muscle itself has not yet been reported, though CAP was reported to relax the isolated guinea-pig stomach by releasing nitric oxide from the CAP-sensitive sensory neurons. Here we showed an evidence that CAP evokes a prolonged relaxation of gastric antral circular smooth muscle(CAP-induced relaxation) by blocking the voltage-operated Ca²+ channels (VOCC) from inside of the cell.