Carvedilol suppresses ventricular arrhythmia in a pressure over-load rabbit model through relieving transmural dispersion of repolarization with long-term administration

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• 作者：Qinghai Yao ; Changcong Cui ; Shangqin Wu ; Sun Shan ; Aijuan Cheng ; Peng Li
• 关键词：Carvedilol ; Pressure over-load ; Left ventricular hypertrophy ; Arrhythmia ; Transmural dispersion of repolarization
• 刊名：Journal of Medical Colleges of PLA
• 出版年：2012
• 出版时间：August, 2012
• 年：2012
• 卷：27
• 期：4
• 页码：198-209
• 全文大小：471 K

文摘

Objective

To investigate the effects of carvedilol (CVD) on transmural dispersion of repolarization (TDR) and arrhythmia in pressure over-load rabbits.

Methods

Left ventricular hypertrophied (LVH) rabbit models were established by pressure over-load; All animal models were assigned into CVD group or LVH group randomly. The action potentials of endocardium, epicardium and transmural ECG of arterially perfused left ventricular preparations were recorded concurrently. Action potential duration (APD), TDR, ventricular arrhythmia and ultrasonic parameters, ratio of LVM to body weight (LVMI) were compared correspondingly. The stable plasma concentration of carvedilol in CVD group was detected by HPLC. APD, TDR and arrhythmia of LVH models were compared just pre- or post-perfusion with stable concentration of CVD.

Results

In Contrast with values in LVH group, LVEF of CVD group were significantly elevated while the LVMI was remarkably reduced, TDRs were significantly shortened, and ratio of ventricular arrhythmia was lowered remarkably. No significant difference of APD, TDR and ratio of arrhythmia was found preor post-perfusion at stable plasma concentration of CVD.

Conclusion

CVD can ameliorate the structure and function of pressure over-load ventricles; CVD contributes to the improvement of ventricular arrhythmia associated with its long-term effect on APD, TDR shortening, whereas has nothing to do with its transient function on ionic channel blockade.