Thermosensitive chitosan-based hydrogel as a topical ocular drug delivery system of latanoprost for glaucoma treatment
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- 作者：Yung-Hsin Chenga ; b ; 1 ; yunghsin@ym.edu.tw" class="auth_mail" title="E-mail the corresponding author ; d97548005@ntu.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Tung-Hu Tsaia ; c ; 2 ; thtsai@ym.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Yong-Yu Jhanb ; 3 ; k45204113@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Allen Wen-hsiang Chiud ; 4 ; whchiu@ym.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Kun-Ling Tsaie ; 5 ; kunlingtsai@mail.ncku.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Chian-Shiu Chienb ; 6 ; polo661124@yahoo.com.tw" class="auth_mail" title="E-mail the corresponding author ; Shih-Hwa Chioub ; f ; shchiou@vghtpe.gov.tw" class="auth_mail" title="E-mail the corresponding author ; Catherine Jui-lin Liud ; f ; jlliu@vghtpe.gov.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chitosan ; Glaucoma ; Latanoprost ; Sustained release
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：25 June 2016
- 年：2016
- 卷：144
- 期：Complete
- 页码：390-399
- 全文大小：2548 K
文摘
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The developed latanoprost-loaded hydrogel showed a sustained release profile.
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The developed hydrogel showed the both in-vitro and in-vivo biocompatibility.
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Intraocular pressure was decreased within 7 days after treatment with the hydrogel.
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Latanoprost acid was detected in the aqueous humor for 7 days.
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The hydrogel may provide a way for long-term intraocular pressure control.