Evaluation of the persistence of functional and biological respiratory health effects in clean-up workers 6 years after the Prestige oil spill
详细信息 查看全文
- 作者：Jan-Paul Zock ; Gema Rodr铆guez-Trigo ; Emma Rodr铆guez-Rodr铆guez ; Ana Souto-Alonso ; Ana Espinosa ; Francisco Pozo-Rodr铆guez ; Federico P. G贸mez ; Carme Fuster ; Gemma Casta帽o-Vinyals ; Josep Maria Ant贸 ; Joan Albert Barber脿
- 关键词：FEV1 ; Forced Expiratory Volume in the first second ; FVC ; Forced Vital Capacity ; FEF25&ndash ; 75% ; Mean Forced Expiratory Flow between 25% and 75% of the FVC ; BHR ; Bronchial Hyperresponsiveness ; EBC ; Exhaled breath condensate ; IL ; Interleukin ; TNF ; Tumour Necrosis Factor ; VEGF ; Vascular Endothelial Growth Factor ; bFGF ; Basic Fibroblast Growth Factor ; SF ; San Francisco quality of life questionnaire ; GM ; Geometric Mean ; SD ; Standard Deviation ; OR ; Odds Ratio
- 刊名：Environment International
- 出版年：January, 2014
- 年：2014
- 卷：62
- 期：Complete
- 页码：72-77
- 全文大小：372 K
文摘
Fishermen who had participated in clean-up activities of the Prestige oil spill showed increased bronchial responsiveness and higher levels of respiratory biomarkers 2 years later. We aimed to evaluate the persistence of these functional and biological respiratory health effects 6 years after clean-up work. In 2008/2009 a follow-up study was done in 230 never-smoking fishermen who had been exposed to clean-up work in 2002/2003 and 87 non-exposed fishermen. Lung function and bronchial responsiveness testing and the determination of respiratory biomarkers in exhaled breath condensate were done identically as in the baseline survey in 2004/2005. Associations between participation in clean-up work and respiratory health parameters were assessed using linear and logistic regression analyses adjusting for sex and age. Information from 158 exposed (69%) and 57 non-exposed (66%) fishermen was obtained. Loss to follow-up in the non-exposed was characterised by less respiratory symptoms at baseline. During the 4-year follow-up period lung function, bronchial hyperresponsiveness and the levels of respiratory biomarkers of oxidative stress and growth factors had deteriorated notably more among non-exposed than among exposed. At follow-up, respiratory health indices were similar or better in clean-up workers than in non-exposed. No clear differences between highly exposed and moderately exposed clean-up workers were found. In conclusion, we could not detect long-term respiratory health effects in clean-up workers 6 years after the Prestige oil spill. Methodological issues that need to be considered in this type of studies include the choice of a non-exposed control group and limitation of follow-up to subgroups such as never smokers.