Aspirin-intolerant asthma in the Korean population: Prevalence and characteristics based on a questionnaire survey

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• 作者：Ji-Yong Moon^a ; Sang-Heon Kim^a ; Tae-Bum Kim^b ; Sae-Hoon Kim^c ; Yoon-Seok Chang^c ; Jae Hyun Lee^d ; You Sook Cho^b ; Jung Won Park^d ; An-Soo Jang^e ; Choon-Sik Park^e ; Dong-Ho Nahm^f ; Young-Joo Cho^g ; Sang-Heon Cho^c ; Byoung-Whui Choi^h ; Hee-Bom Moon^b ; Ho Joo Yoon^a ; ^{hjyoon@hanyang.ac.kr} ; For the COREA study group
• 关键词：Aspirin-intolerant asthma ; Prevalence ; Characteristics
• 刊名：Respiratory Medicine
• 出版年：2013
• 出版时间：February, 2013
• 年：2013
• 卷：107
• 期：2
• 页码：202-208
• 全文大小：163 K

文摘

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Summary

Background

Aspirin-intolerant asthma is a unique clinical syndrome characterized by acute bronchoconstriction following the administration of aspirin and/or non-steroidal anti-inflammatory drugs.

Objective

We assessed the prevalence and investigated the demographic and clinical characteristics of adult patients with aspirin-intolerant asthma in Korea.

Methods

Using an adult asthma cohort (COREA) from 11 university hospitals in Korea, we analyzed the prevalence of aspirin-intolerant asthma, defined as a positive response to the question: ¡°Have you ever experienced dyspnea and cough after taking an aspirin or any NSAID (cold medicine)?¡± Demographic and clinical characteristics were compared between patients with aspirin-intolerant asthma and aspirin-tolerant asthma.

Results

Aspirin-intolerant asthma was reported in 68 (5.8 % ) of 1173 adult asthmatics (age 15-84). Patients with aspirin-intolerant asthma had a lower mean age (43.9?¡À?13.4 vs. 49.0?¡À?15.6, P?=?0.003) and a higher prevalence of rhinosinusitis (77.9 % vs. 61.7 % , P?=?0.012) and atopic dermatitis (16.2 % vs. 5.7 % , P?=?0.001) than aspirin-tolerant asthma patients. There were no significant differences in lung function, asthma severity or the use of asthma controllers. However, aspirin-intolerant asthma was associated with greater use of healthcare services over a lifetime and over the past 12 months. Aspirin-intolerant asthma was significantly associated with emergency room visits over the past 12 months (P?=?0.029, OR 2.19, 95 % CI 1.08-4.42).

Conclusion

Based on histories, the prevalence of aspirin-intolerant asthma is 5.8 % among adult asthma patients in Korea. Aspirin-intolerant asthma is associated with lower age, higher prevalence of rhinosinusitis and atopic dermatitis, and more frequent exacerbations.