Higher prevalence of cancer related mutations 1762T/1764A and PreS deletions in hepatitis B virus (HBV) isolated from HBV/HIV co-infected compared to HBV-mono-infected Chinese adults

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• 作者：Kai-Wen Li^a ; ^b ; Anna Kramvis^c ; Shujia Liang^a ; Xiang He^d ; Qin-Yan Chen^a ; Chao Wang^a ; Qing-Li Yang^a ; Li-Ping Hu^a ; ^b ; Hui-Hua Jia^a ; ^b ; Zhong-Liao Fang^a ; ^{zhongliaofang@hotmail.com}
• 关键词：Hepatitis B virus (HBV) ; Human immunodeficiency virus (HIV) ; Co-infection ; Mutations ; Prevalaence ; Genotype
• 刊名：Virus Research
• 出版年：2017
• 出版时间：2 January 2017
• 年：2017
• 卷：227
• 期：Complete
• 页码：88-95
• 全文大小：514 K
• 卷排序：227

文摘

Co-infection with HIV was associated with increased prevalence of BCP double mutations in HBV isolated from Chinese patients. Co-infection with HIV was associated with increased prevalence of preS deletions in HBV isolated from Chinese patients. HCC-related HBV mutations occurred more frequently in genotypes C and I, compared to genotype B. Co-infection with HIV was associated with increased prevalence of MHR mutations.