Clinical challenges in HIV/AIDS: Hints for advancing prevention and patient management strategies

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• 作者：Omar Sued ; ^{omar.sued@huesped.org.ar" class="auth_mail" title="E-mail the corresponding author} ; Marí ; a Iné ; s Figueroa ^{maria.figueroa@huesped.org.ar" class="auth_mail" title="E-mail the corresponding author} ; Pedro Cahn ^{pcahn@huesped.org.ar" class="auth_mail" title="E-mail the corresponding author}
• 关键词：AIDS ; Acquired immune deficiency syndrome ; ACTG ; AIDS Clinical Trials Group ; ART ; Antiretroviral therapy ; BID ; twice a day ; CNS ; Central nervous system ; CWS ; Commercial sex worker ; DNA ; Deoxyribonucleic acid ; DHHS ; Department of Health and Human Services ; EACS ; European AIDS Clinical Society ; EC ; Elite controllers ; FDA ; Food and Drug Administration ; HAART ; Highly activity antiretroviral therapy ; HDACi ; Histone deacetylase Inhibitor ; HIV ; Human immunodeficiency virus ; HPV ; Human papillomavirus ; H
• 刊名：Advanced Drug Delivery Reviews
• 出版年：2016
• 出版时间：1 August 2016
• 年：2016
• 卷：103
• 期：Complete
• 页码：5-19
• 全文大小：762 K

文摘

Acquired immune deficiency syndrome has been one of the most devastating epidemics of the last century. The current estimate for people living with the HIV is 36.9 million. Today, despite availability of potent and safe drugs for effective treatment, lifelong therapy is required for preventing HIV re-emergence from a pool of latently infected cells. However, recent evidence show the importance to expand HIV testing, to offer antiretroviral treatment to all infected individuals, and to ensure retention through all the cascade of care. In addition, circumcision, pre-exposure prophylaxis, and other biomedical tools are now available for included in a comprehensive preventive package. Use of all the available tools might allow cutting the HIV transmission in 2030. In this article, we review the status of the epidemic, the latest advances in prevention and treatment, the concept of treatment as prevention and the challenges and opportunities for the HIV cure agenda.