An in-depth snake venom proteopeptidome characterization: Benchmarking Bothrops jararaca

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• 作者：Carolina A. Nicolau^a ; ^e ; Paulo C. Carvalho^a ; ^b ; Iná ; cio L.M. Junqueira-de-Azevedo^c ; André ; Teixeira-Ferreira^a ; ^e ; Magno Junqueira^d ; ^e ; Jonas Perales^a ; ^e ; Ana Gisele C. Neves-Ferreira^a ; ^e ; Richard H. Valente^a ; ^e ; ^{richardhemmi@gmail.com} ; ^{rhv4u@ioc.fiocruz.br}
• 关键词：Bothrops jararaca ; Cryptome ; OFFGEL ; Proteopeptidome ; Proteomics ; Snake venomics
• 刊名：Journal of Proteomics
• 出版年：2017
• 出版时间：16 January 2017
• 年：2017
• 卷：151
• 期：Complete
• 页码：214-231
• 全文大小：1649 K
• 卷排序：151

文摘

Our experimental strategy pushes venomics towards ubiquitous protein-level assignment. An unprecedented diversity for Bothrops jararaca venom was demonstrated. Some typical Elapidae venom components were identified in this Viperidae's venom. Several lysosomal-derived proteins are present in B. jararaca venom. The highly diverse peptidome of B. jararaca may represent a source of cryptides