When LIN41 Comes to a Fork in the Road, It Takes BOTH Paths: Translational Repression OR mRNA Decay, Depending on the Target Site Position

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• 作者：Jacqelyn M. Hand¹ ; Ariel A. Bazzini¹ ; ² ; ^{arb@stowers.org}
• 关键词：RNA-binding protein ; mRNA decay ; translation repression ; early development ; gene regulation
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：2 February 2017
• 年：2017
• 卷：65
• 期：3
• 页码：375-377
• 全文大小：388 K
• 卷排序：65

文摘

In this issue, Aeschimann et al. (2017) demonstrate that, depending on the target location site (5′UTR or 3′UTR), LIN41 triggers repression of translation or mRNA decay, suggesting that one factor may use two independent pathways of post-transcriptional gene regulation.