Dnd Is a Critical Specifier of Primordial Germ Cells in the Medaka Fish
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- 作者：Ni Hong1 ; 2 ; 5 ; Mingyou Li3 ; 5 ; Yongming Yuan1 ; Tiansu Wang1 ; Meisheng Yi4 ; Hongyan Xu1 ; Huaqiang Zeng2 ; Jianxing Song1 ; dbssjx@nus.edu.sg" class="auth_mail" title="E-mail the corresponding author ; Yunhan Hong1 ; dbshyh@nus.edu.sg" class="auth_mail" title="E-mail the corresponding author
- 关键词：asymmetric segregation ; dnd ; lineage tracing ; primordial germ cell ; RNA particle ; single-cell culture
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：8 March 2016
- 年：2016
- 卷：6
- 期：3
- 页码：411-421
- 全文大小：2797 K
文摘
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The medaka RNA-binding protein Dnd specifies primordial germ cells
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Cells from medaka cleavage embryos can be singly cultured for lineage tracing
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The dnd RNA forms particles as a new mechanism for asymmetric segregation
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These findings offer new insights into PGC specification and manipulation