The effects of evening primrose oil on lipid peroxidation induced by subacute aflatoxin exposure in mice

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• 作者：Murat Kanbur^a ; Gö ; khan Eraslan^a ; ^{geraslan38@hotmail.com"" rel=""nofollow} ; Zeynep Soyer Sarı ; ca^a ; Ö ; znur Aslan^b
• 关键词：Aflatoxin ; Evening primrose oil ; Lipid peroxidation ; Antioxidant effect ; Mice
• 刊名：Food and Chemical Toxicology
• 出版年：2011
• 出版时间：September 2011
• 年：2011
• 卷：49
• 期：9
• 页码：1960-1964
• 全文大小：190 K

文摘

The present study was aimed at the investigation of the antioxidative effect of evening primrose oil in cases of subacute aflatoxin (AF) intoxication induced in mice. For this purpose, forty-eight 6–8-week-old male BALB/c mice, weighing 30–35 g, were used. The animals were allocated to four groups, each comprising of 12 mice, such that one group was maintained as the control group and the other three constituted the trial groups. The mice included in the control group (Group 1) were not subjected to any treatment. Group 2 was administered with 1.5 ml/kg bw/day of evening primrose oil; Group 3 received 1250 μg/kg bw/day of AF (82.45 % AFB₁, 10.65 % AFB₂, 4.13 % AFG₁ and 2.77 % AFG₂) and Group 4 was given 1250 μg/kg bw/day of AF plus 1.5 ml/kg bw/day of evening primrose oil using a catheter, for a period of 14 days. At the end of the 14th day, the liver, lungs, kidneys, brain, heart and spleen of the animals included in all groups were extracted. Malondialdehyde (MDA) levels and superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidise (GSH-Px) activities were measured in tissue homogenates. In result, it was concluded that, evening primrose oil had a positive effect on aflatoxin-induced lipid peroxidation.