- 作者：Soheila Rezapour-Firouzi ; Seyed Rafie Arefhosseini ; Farhoudi Mehdi ; Ebrahimi-Mamaghani Mehrangiz ; Behzad Baradaran ; Elyar Sadeghihokmabad ; Somaiyeh Mostafaei ; Seyed Mohammad Bagher Fazljou ; Mohammad-ali Torbati ; Sarvin Sanaie ; Fatemeh Zamani
- 关键词：AA ; arachidonic acid ; ALA ; alpha-linolenic acid ; CMF ; cell membrane fluidity ; CNS ; central nervous system ; D6D ; (FADS2)delta-6-desaturase ; DGLA ; dihomo-gamma-linolenic acid ; DHA ; docosahexanoic acid (key omega-3) ; EDSS ; Expanded Disability Status Scale ; E
- 刊名：Complementary Therapies in Medicine
- 出版年：2013
- 出版时间：October, 2013
- 年：2013
- 卷：21
- 期：5
- 页码：473-480
- 全文大小：697 K
Summary
Background
Multiple sclerosis (MS) is the most chronic and inflammatory disorder. Because of limited efficacy and adverse side effects, identifying novel therapeutic and protective agents is important. This study was aimed to assess the potential therapeutic effects of hemp seed and evening primrose oils as well as Hot-nature dietary intervention on RRMS patients.Methods and materials
In this double blind, randomized trial, 100 MS patients with EDSS < 6 were allocated into 3 groups: ¡°Group A¡± who received co-supplemented hemp seed and evening primrose oils with advised Hot-nature diet, ¡°Group B¡± who received olive oil, ¡°Group C¡± who received the co-supplemented oils. Mizadj, clinically EDSS and relapse rate as well as immunological factors (IL-4, IFN-¦Ã and IL-17) were assessed at baseline and after 6 months.
Results
Mean follow-up was 180 ¡À 2.9 SD days (N = 65, 23 M and 42 F aged 34.25 ¡À 8.07 years with disease duration 6.80 ¡À 4.33 years). There was no significant difference in studies parameters at baseline. After 6 months, significant improvements in Mizadj, EDSS and relapse rate were found in the groups A and C, while the group B showed a border significant decrease in relapse rate. Immunological parameters showed improvement in groups A and C, whereas there was worsening condition for group B after the intervention.
Conclusion
The co-supplemented hemp seed and evening primrose oils with Hot-nature diet have beneficial effects in improving of clinical score in RRMS patients which were confirmed by immunological findings.