To determine circulating serum leptin and resistin levels and to correlate these levels in relation to the metabolic factors in pre- and postmenopausal women.
A cross-sectional study was carried out on 34 individuals who were postmenopausal and 31 individuals who had regular menstruation among south Indian rural women. Anthropometric indices, blood pressure, fasting blood sugar (FBS), fasting lipid profile, fasting leptin, and fasting resistin levels were measured.
In a total of 65 women, the mean age of the premenopausal group was 38.65聽卤聽6.21 years and that of the postmenopausal group was 55.32聽卤聽6.32 years. The fasting serum leptin level was increased considerably in postmenopausal women when compared to premenopausal women (p聽=聽0.018). Resistin had no significant relationship with metabolic factors except body mass index (BMI) in both of the groups. Triglycerides (TG) and FBS were lower in the premenopausal group when compared to the postmenopausal group (p聽<聽0.001). Leptin was well correlated with BMI in premenopausal women (r2聽=聽0.7120, p聽<聽0.0001) as well as postmenopausal women (r2聽=聽0.2470, p聽=聽0.0028). Leptin also had a significant correlation with FBS in both pre- (r2聽=聽0.1373, p聽=聽0.0402) and post-menopausal women (r2聽=聽0.2141, p聽=聽0.0401). Systolic blood pressure (SBP) was positively associated with leptin levels in postmenopausal women (p聽<聽0.001).
Leptin was found to have significant association with metabolic factors when compared to resistin in pre- and postmenopausal women and there is no doubt that association of BMI and FBS elevates the level of leptin in both categories.