Naringenin type phytoestrogens bind ER subtypes with different affinities.
8-PN, 6-DMAN and Nar induce mitotic effects in MCF-7 cells.
8-PN and 6-DMAN treatment display proliferative effects on the mammary gland of rats.
Proliferative responses in the mammary gland are weak compared to E2 treatment.