Methylation of tumor suppressor gene CDH13 and SHP1 promoters and their epigenetic regulation by the UHRF1/PRMT5 complex in endometrial carcinoma
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- 作者：Yan Shenga ; b ; 1 ; Hongtao Wangc ; 1 ; Dongchen Liua ; Cheng Zhanga ; Yupeng Denga ; Fan Yanga ; Tingguo Zhanga ; ztguo@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Cuijuan Zhanga ; cuijuanzhang@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Endometrial carcinoma ; DNA methylation ; Epigenetics ; Tumor suppressor genes
- 刊名：Gynecologic Oncology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：140
- 期：1
- 页码：145-151
- 全文大小：877 K
文摘
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SHP1 methylation has high specificity for diagnosis of endometrial carcinoma.
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CDH13 methylation plays a role in the precancerous stage of endometrial lesion.
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Methylation of CDH13 and SHP1 can be reversed by 5-Aza-CdR or TSA.
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UHRF1 could form a complex with PRMT5 to contribute to the endometrial carcinogenesis.