We studied 684 patients (94% male, age 61.2 ± 11.2, left ventricular ejection fraction [LVEF] < 35%–45%, NYHA class (I/II/III/IV: 8.4/45.8/39.5/6.3%), ischaemic aetiology 71%, body mass index [BMI] 26.5 ± 4.3 kg/m2, mean MR-proANP 296.0 ± 281.0 pmol/L, mean NT-proBNP 2792.0 ± 5328.6 pg/mL, mean creatinine level 110.2 ± 38.0 μmol/L and mean haemoglobin 13.9 ± 1.5 g/dL) with clinically stable chronic heart failure. MR-proANP levels increased with increasing NYHA class (p < 0.0001) and an increasing BMI category was associated with decreasing values of MR-proANP (p < 0.0001). We found MR-proANP to be independently associated with BMI, creatinine, ischaemic aetiology, LVEF and NYHA class. Meanwhile, NT-proBNP was independently associated with BMI, creatinine, haemoglobin, LVEF and NYHA class.
MR-proANP is subject to the almost identical influencing factors like NT-proBNP. The effects of anaemia warrant further study.