High levels of atrial natriuretic peptide and copeptin and mortality risk

详细信息    查看全文

• 作者：Corsino Rey^a ; ^b ; ^c ; ^{crey@uniovi.es} ; ^{corsino.rey@sespa.princast.es} ; Clara Garcí ; a-Cendó ; n^d ; Pablo Martí ; nez-Camblor^e ; ^f ; Jesú ; s Ló ; pez-Herce^c ; ^g ; ^h ; André ; s Concha-Torre^a ; Alberto Medina^a ; Ana Vivanco-Allende^a ; Juan Mayordomo-Colunga^a
• 关键词：Mortality risk ; Organ failure ; Prognosis ; Atrial natriuretic peptide ; Copeptin ; Procalcitonin ; Critically ill children
• 刊名：Anales de Pediatría (English Edition)
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：85
• 期：6
• 页码：284-290
• 全文大小：773 K
• 卷排序：85

文摘

To determine whether high levels of mid-regional pro-atrial natriuretic peptide (MR-proANP), copeptin, and procalcitonin (PCT) plasma concentrations are associated with increased mortality risk.MethodsProspective observational study including 254 critically ill children. MR-proANP, copeptin and PCT were compared between children with high (Group A; n = 33) and low (Group B; n = 221) mortality risk, and between patients with failure of more than 1 organ (Group 1; n = 71) and less than 2 (Group 2; n = 183).ResultsMedian (range) of MR-proANP, copeptin, and PCT levels in group A vs B were, respectively: 209.4 (30.5–1415.8) vs. 75.0 (14.6–867.2) pmol/L (P < .001); 104.4 (7.4–460.9) vs. 26.6 (0.00–613.1) pmol/L (P < .001), and 7.8 (0.3–552.0) vs. 0.3 (0.02–107.0) ng/mL (P < .001). The area under the curve (AUC) for the differentiation of group A and B was 0.764 (95% CI: 0.674–0.854) for MR-proANP; 0.735 (0.642–0.827) for copeptin, and 0.842 (0.744–0.941) for PCT, with no statistical differences. The AUCs for the differentiation of group 1 and 2 were: 0.837 (0.784–0.891) for MR-proANP, 0.735 (0.666–0.804) for copeptin, and 0.804 (0.715–0.892) for PCT, with statistical differences between MR-proANP and copeptin, P=.01.ConclusionsHigh levels of MR-proANP, copeptin and PCT were associated with increased mortality risk scores. MR-proANP showed a higher association than copeptin with number of organs in failure.