Targeting the pseudorabies virus DNA polymerase processivity factor UL42 by RNA interference efficiently inhibits viral replication
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- 作者：Yi-Ping Wang ; Li-Ping Huang ; Wen-Juan Du ; Yan-Wu Wei ; Hong-Li Wu ; Li Feng ; Chang-Ming Liu ; lcm@hvri.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pseudorabies virus ; DNA polymerase ; Processivity factor ; UL42 ; RNA interference
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：132
- 期：Complete
- 页码：219-224
- 全文大小：1475 K
文摘
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The PRV processivity factor UL42 was expressed with early kinetics during viral replication.
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Small interfering RNAs targeting UL42 were designed to inhibit PRV replication.
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UL42-targeted RNA interference inhibited target gene expression and impaired viral replication in cell culture.
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Targeting UL42 is a novel antiviral strategy against PRV infection.