Cochlear sensitivity in children with chronic kidney disease and end-stage renal disease undergoing hemodialysis

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• 作者：Rahime Renda^a ; ^{rahimeg@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Levent Renda^b ; Ö ; mer Tarık Selç ; uk^b ; Hü ; lya Eyigö ; r^b ; Mustafa Deniz Yılmaz^b ; Ü ; stü ; n Osma^b
• 关键词：Otoacoustic emissions ; Hearing loss ; Hemodialysis ; Chronic kidney disease
• 刊名：International Journal of Pediatric Otorhinolaryngology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：79
• 期：12
• 页码：2378-2383
• 全文大小：984 K

文摘

Auditory system abnormalities commonly occur in patients with chronic renal disease and end-stage renal disease undergoing hemodialysis. The aim of this study was to determine the relationship between cochlear sensitivity and hemodialysis in dialytic and non-dialytic chronic kidney disease patients.

Methods

The study included children aged 6–18 years that were divided into 3 groups: 36 non-dialytic patients with chronic kidney disease, 16 end-stage renal disease patients undergoing hemodialysis, and 30 healthy controls. Blood urea nitrogen, serum cystatin C levels, duration of chronic kidney disease, and the duration of hemodialysis were compared between the chronic kidney disease patients and end-stage renal disease patients undergoing hemodialysis. Hearing health was measured via tympanometry, pure-tone audiometry and distortion product otoacoustic emissions testing.

Results

Distortion product otoacoustic emission amplitudes and signal-to-noise ratios were significantly lower at all frequencies tested in the non-dialytic and dialytic groups than in the control group (p < 0.05). Patients with normal hearing had significantly lower distortion product otoacoustic emission amplitudes and signal-to-noise ratios than the healthy controls (p < 0.05). The duration of CKD, the cystatin C level, and the blood urea level were not associated with hearing loss. The present findings suggest that there was a significant association between the duration of HD and hearing loss.

Conclusion

The present findings show that there was impaired cochlear function in the dialytic and non-dialytic patient groups, regardless of hearing loss, as compared to the control group. Patients with chronic renal disease—both dialytic and non-dialytic—should be monitored to prevent any further deterioration by avoiding potential ototoxic agents, even if their hearing thresholds are within normal limits.