Fatty acid biosynthesis is involved in the production of hepatitis B virus particles
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- 作者：Hitomi Okamuraa ; b ; Yasunori Nioc ; yasunori.nio@takeda.com" class="auth_mail" title="E-mail the corresponding author ; Yuichi Akahoria ; b ; Sulyi Kima ; Koichi Watashid ; e ; f ; Takaji Wakitad ; Makoto Hijikataa ; b ; mhijikat@virus.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hepatitis B virus ; Fatty acid biosynthesis ; Viral particle production
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：17 June 2016
- 年：2016
- 卷：475
- 期：1
- 页码：87-92
- 全文大小：811 K
文摘
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Inhibitors of ACC1 and FAS but not SCD1 decreased production of extracellular HBV DNA.
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Products of FABS, long chain fatty acids, increased production of extracellular HBV DNA.
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FAS inhibitor increased intracellular levels of HBV DNA and HBcAg.
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FABS was suggested to contribute to HBV particle production without significant relation with secretory pathway of the cells.