Nonviral vector plasmid DNA encoding human proenkephalin gene attenuates inflammatory and neuropathic pain-related behaviors in mice
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- 作者：Chunsheng Hua ; b ; Zhenzhen Caia ; Yuxin Lua ; Xiaochen Chenga ; Qi Guoa ; Zuze Wua ; b ; Qinglin Zhanga ; qinglz@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Plasmid ; Proenkephalin ; Gene transfer ; Pain behavior
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：10 November 2016
- 年：2016
- 卷：634
- 期：Complete
- 页码：87-93
- 全文大小：1755 K
文摘
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Peripheral or spinal delivery of pVAX1-PENK alleviates CFA-induced pain for an extended period.
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Peripheral or spinal delivery of pVAX1-PENK attenuates SNI-induced nocifensive behaviors in mice.
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The analgesic effect of pVAX1-PENK is blocked by naloxone hydrochloride.