Fabrication of an ionic-sensitive in situ gel loaded with resveratrol nanosuspensions intended for direct nose-to-brain delivery
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- 作者：Jifu Haoa ; 1 ; haojifu@163.com" class="auth_mail" title="E-mail the corresponding author ; Jing Zhaoa ; 1 ; Shupeng Zhangb ; Tiantian Tonga ; Qiannan Zhuanga ; Kai Jina ; Wei Chena ; ; Hua Tanga ; tanghuazhang218@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Resveratrol ; Gellan gum ; In situ gel ; Intranasal drug delivery
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：147
- 期：Complete
- 页码：376-386
- 全文大小：2642 K
文摘
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A composite hybrid system has been tailored for challenging nasal drug delivery.
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The profile of ionic-sensitive hydrogel was evaluated by textural analysis.
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DTE and DTP demonstrated the direct delivery via the nose-brain pathway.
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Distribution and localization further showed direct nose to brain transport route.