Effects of abalone (Haliotis discus hannai Ino) gonad polysaccharides on cholecystokinin release in STC-1 cells and its signaling mechanism
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- 作者：Jun Zhaoa ; b ; Da-Yong Zhouc ; d ; e ; Jing-Feng Yangc ; d ; e ; Shuang Songc ; d ; e ; Ting Zhangc ; d ; Ce Zhuc ; d ; Yan-Qing Songc ; d ; Chen-Xu Yuc ; d ; f ; Bei-Wei Zhua ; c ; d ; e ; zhubeiwei@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ADP ; adenosine diphosphate ; ATP ; adenosine triphosphate ; AGP ; abalone gonad polysaccharide ; ANOVA ; analysis of variance ; BAGP-32 ; backbone fraction of AGP-32 ; CaM ; calmodulin ; CaMK ; calmodulin-dependent protein kinase ; cAMP ; cyclic adenosine monophosphate ; CaSR ; calcium-sensing receptor ; CCK ; cholecystokinin ; DMEM ; Dulbecco&rsquo ; s modified Eagle&rsquo ; s medium ; DMSO ; dimethyl sulphoxide ; EIA ; enzyme immunoassay ; KATP ; adenosine triphosphate sensitive potassium ; MAPK ; mitogen-activated protein k
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：20 October 2016
- 年：2016
- 卷：151
- 期：Complete
- 页码：268-273
- 全文大小：671 K
文摘
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Sulfated polysaccharides, AGP-31, 32 and 33 were purified from abalone gonad.
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AGPs have similar monosaccharide profile but different molecular weights.
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All the AGPs could significantly increase the secretion of CCK in STC-1 cells.
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Ca2+/CaM/CaMK, cAMP/PKA and MAPK pathways are involved in CCK secretion by AGPs.