Determination of clozapine, and five antidepressants in human plasma, serum and whole blood by gas chromatography-mass spectrometry: A simple tool for clinical and postmortem toxicological analysis
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- 作者：Vassiliki A. Boumba ; Ph.D.a ; vboumba@uoi.gr" class="auth_mail" title="E-mail the corresponding author ; vassiliki.boumba@gmail.com" class="auth_mail" title="E-mail the corresponding author (Assistant Professor) ; George Rallisa ; Petros Petrikisb ; Theodore Vougiouklakisa ; Venetsanos Mavreasb
- 关键词：Clozapine ; Antidepressants ; Monitoring ; GC&ndash ; MS ; Autopsy
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：1038
- 期：Complete
- 页码：43-48
- 全文大小：788 K
文摘
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GC-MS method for clozapine, bupropion, mirtazapine, sertraline, clomipramine and citalopram in serum, plasma and whole blood.
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It is selective, sensitive, accurate and precise with no derivatization steps.
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It shows comparable analytical effectiveness between serum, plasma and whole blood.
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It relies on simple and basic analytical instrumentation.
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Suitable for routine clinical and postmortem toxicological analysis.