Ribosome profiling reveals an adaptation strategy of reduced bacterium to acute stress

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• 作者：Gleb Y. Fisunov^a ; ^{herr.romanoff@gmail.com} ; Daria V. Evsyutina^a ; ^b ; Irina A. Garanina^a ; ^c ; Alexander A. Arzamasov^a ; Ivan O. Butenko^a ; Ilya A. Altukhov^a ; Anastasia S. Nikitina^a ; ^d ; Vadim M. Govorun^a ; ^c ; ^d
• 关键词：Mollicutes ; Mycoplasma ; Ribosome profiling ; Proteome ; Stress
• 刊名：Biochimie
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：132
• 期：Complete
• 页码：66-74
• 全文大小：1120 K
• 卷排序：132

文摘

Mycoplasma gallisepticum demonstrate high correlation between transcription and translation under growth at normal temperature, but low under heat stress. Stress response of M. gallsiepticum consists of a noise-like response which envolves numerous genes and an adaptive one. Decrease of promoters' efficiency during the stress significantly contributes to the ribosome-bound mRNA. HU-protein is associated with ribosomes under growth at normal temperature but dissociates under heat stress.