Early life disruption to the ghrelin system with over-eating is resolved in adulthood in male rats

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• 作者：Luba Sominsky^a ; ¹ ; ^{Luba.Sominsky@rmit.edu.au} ; Ilvana Ziko^a ; ¹ ; Thai-Xinh Nguyen^a ; Zane B. Andrews^b ; Sarah J. Spencer^a
• 关键词：Obesity ; Perinatal programming ; Fluorescently-labelled ghrelin ; Feeding ; Metabolism
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：113
• 期：part_PA
• 页码：21-30
• 全文大小：1594 K
• 卷排序：113

文摘

Early life overfeeding reduces circulating des-acyl, but not acyl ghrelin levels acutely. Neuronal responses to acyl ghrelin and ghrelin's access to the brain are affected by neonatal diet. Neonatal overfeeding-induced changes to the ghrelin system are resolved in adulthood.