DNA damage response regulation by microRNAs as a therapeutic target in cancer

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• 作者：Maryam Majidinia^a ; ^b ; ^c ; Bahman Yousefi^b ; ^c ; ^d ; ^{yousefib@tbzmed.ac.ir" class="auth_mail" title="E-mail the corresponding author}
• 关键词：DNA damage response ; DNA repair ; Cancer ; Chemotherapy ; microRNA
• 刊名：DNA Repair
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：47
• 期：Complete
• 页码：1-11
• 全文大小：1895 K

文摘

The inability of cancer cells in taking care of DNA damages can lead to cancer development and/or progression. Due to the essential role of DNA repair in maintaining genomic stability, tightly controlled regulatory mechanism are required for these processes. Recent studies have shown a myriad of interactions among DNA damage response (DDR) components and miRNAs. While DDR modulates miRNA expression in transcriptional and post-transcriptional levels and affects miRNA degradation, miRNAs in turn, directly modulate the expression of multiple proteins in the DDR pathways, or indirectly fine-tune the expression of such proteins. A better understanding of DDR-miRNA interactions can facilitate the development of new anticancer agents targeting miRNAs involved in the DNA repair process. In this review, we provide a brief introduction about miRNA biogenesis and functions, DDR pathways, and recent findings about DDR-microRNA interactions. Finally, the therapeutic importance of miRNAs in modulation of DDR/DNA repair mechanisms will be discussed.