Progressive development of endometriosis and its hindrance by anti-platelet treatment in mice with induced endometriosis

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• 作者：Qi Zhang^a ; ¹ ; Xishi Liu^a ; ^b ; ¹ ; Sun-Wei Guo^a ; ^b ; ^{hoxa10@outlook.com}Author Vitae
• 关键词：endometriosis ; epithelial-mesenchymal transition ; fibroblast-to-myofibroblast transdifferentiation ; fibrosis ; platelet ; smooth muscle metaplasia
• 刊名：Reproductive BioMedicine Online
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：34
• 期：2
• 页码：124-136
• 全文大小：5981 K
• 卷排序：34

文摘

Endometriotic lesions undergo progressive platelet aggregation. Lesions show cellular changes consistent with progressive EMT and FMT as they aged. This orderly progression led to increased smooth muscle metaplasia (SMM) and fibrosis. A few select immunostaining and histochemistry markers can date these lesions well. Anti-platelet treatment impedes the progressive EMT, FMT, SMM and fibrogenesis.